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Simparica Trio
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The first months of a puppy's life are when parasite protection matters most — and Simparica Trio gives you the most complete protection available in a single monthly chew. Designed for the smallest dogs and puppies weighing 2.8–5.5 lbs (1.25–2.5 kg), this liver-flavored chewable tablet covers heartworm disease, fleas, six species of ticks, roundworms, and hookworms from just 8 weeks of age. No prescription required when you order from Smartway Pet Supplies — genuine Zoetis product shipped direct to the USA and Canada.
Heartworm disease is transmitted by a single mosquito bite and can be fatal if left untreated. Starting your puppy on Simparica Trio early gives them continuous monthly protection against Dirofilaria immitis. In studies to support FDA approval, one monthly dose provided 100% protection against heartworm disease.
Simparica Trio begins killing fleas within 4 hours of the first dose and achieves 100% flea kill within 8 hours. Crucially, it kills fleas before they can lay eggs — breaking the infestation cycle in your home rather than just treating the dog. Flea allergy dermatitis (FAD) is one of the most common skin conditions in dogs; consistent monthly protection prevents it before it starts. Simparica Trio also eliminates fleas that carry flea tapeworm larvae, preventing Dipylidium caninum infection.
Simparica Trio is the first combination preventive proven to kill six species of ticks — more than any competing oral monthly chewable:
Simparica Trio is FDA-approved to prevent infections that may cause Lyme disease by killing black-legged deer ticks before they can transmit Borrelia burgdorferi. It is the only combination monthly chewable with this specific FDA indication — important for dogs in the Northeast, Mid-Atlantic, Midwest, and Pacific Northwest where Lyme disease risk is highest.
Pyrantel treats and controls intestinal roundworm (Toxocara canis, Toxascaris leonina) and hookworm (Ancylostoma caninum, Uncinaria stenocephala) infections. For puppies especially — who are at higher risk of roundworm infection from their mother — this is an important part of routine deworming.
Simparica Trio was the first FDA-approved product to combine all three of these proven active ingredients:
One chew effectively replaces the work of two or three separate monthly treatments.
Yes. At Smartway Pet Supplies, you can purchase Simparica Trio without a prescription. We are an Australian-based retailer, and Australian regulations allow the sale of this product without a prescription requirement. Customers are responsible for ensuring their order complies with import regulations in their destination country.
Absolutely. We sell only 100% authentic, brand-name Simparica Trio manufactured by Zoetis. All products are sourced from licensed Australian veterinary wholesalers and arrive in original, manufacturer-sealed packaging. You will never receive grey-market, repackaged, or counterfeit product from Smartway.
Standard shipping to the USA typically takes 7–14 business days. Orders over $125 qualify for FREE standard shipping. Express options are available at checkout.
Yes. Simparica Trio can be started at any time of year. For the best protection, begin monthly doses before ticks or mosquitoes become active in your region and continue year-round without interruption.
If your dog has never been on heartworm prevention or has had a lapse in coverage, a heartworm test is recommended before starting. This is because giving a preventive to a dog that already has adult heartworms can cause a reaction. Consult your vet if you're unsure.
If vomiting occurs within an hour of dosing, re-administer a full replacement dose. Giving the chew with a small amount of food can reduce the chance of an upset stomach.
Simparica contains only sarolaner and covers fleas and ticks. Simparica Trio adds moxidectin and pyrantel, extending coverage to heartworm disease, roundworms, and hookworms. For most dog owners, Simparica Trio is the better choice because it replaces multiple products in one monthly chew.
Use with caution. Sarolaner is a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in some dogs. If your dog has a history of seizures or neurological disorders, discuss with your vet before starting.
this seems to be helping with the fleas so far and I was also worried about worms and that seems to be taken care of as well. Thank you so much for making. This is very smooth quick and easy process. received my order very quickly, much sooner than I expected.
Great on shipping. Very good price.
Excellent product
Even though I have to pay duties for this product to come to Canada 🇨🇦 it's still cheaper than getting it from the vet.
Plus having auto reorder is great except when you forget that it's set up and order the item again. 😀
Fast shipping, frequent communication from the seller! Very easy to do business with!
This is a great company to buy prescription meds for your pets without the need for a vet bill. I ordered from another company and never received my order. When I ordered from Smartway they let me know what was going on every step of the way. Also order arrived before it was supposed to.
Great product! The best flea pill on the market IMO!
everything is good
