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Simparica Trio
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Large breeds live big lives — more time outdoors, more exposure to ticks in parks and trails, more ground covered on walks and hikes. That means more parasite risk, and a stronger case for the most comprehensive monthly prevention available. Simparica Trio Green is designed for dogs weighing 44.3–88 lbs (20.1–40 kg), covering Labrador Retrievers, Golden Retrievers, German Shepherds, Boxers, Dobermans, and similar large breeds with a single monthly liver-flavored chew. Heartworm disease, fleas, six tick species including Lyme-carrying deer ticks, roundworms, and hookworms — all in one dose. No prescription required at Smartway Pet Supplies.
Heartworm is transmitted by mosquitoes and has been diagnosed in every US state, including Alaska and Hawaii. Adult heartworms live in the heart and pulmonary arteries, causing progressive respiratory and cardiovascular damage. Treatment for established infection is harsh, expensive, and carries real risk. With Simparica Trio, prevention is simple: one chew monthly. Moxidectin stops Dirofilaria immitis larvae from developing before they can establish. Studies to support FDA approval demonstrated 100% protection against heartworm disease with a single monthly dose.
Fleas don't just bite — they spread disease, trigger allergic skin reactions, and infest your home environment within weeks of an uncontrolled infestation. Simparica Trio begins killing adult fleas in just 4 hours after dosing, achieving 100% flea mortality by 8 hours. Killing fleas before they can lay eggs is critical: it breaks the infestation cycle at the source rather than playing catch-up after eggs, larvae, and pupae have already contaminated your floors and furniture. Simparica Trio also eliminates the carrier fleas that transmit Dipylidium caninum flea tapeworm.
Ticks transmit over 15 serious diseases to dogs and are responsible for emerging zoonotic threats like the Asian longhorned tick. Simparica Trio provides proven, 30-day protection against all six major tick species in North America:
Simparica Trio is FDA-approved to prevent infections that may cause Lyme disease — a specific indication earned by demonstrating that killing black-legged deer ticks prevents Borrelia burgdorferi transmission. Active large dogs in tick-prone regions face real Lyme risk: the disease causes joint pain, lameness, fever, and in severe cases, protein-losing nephropathy. Monthly Simparica Trio is the most practical, comprehensive prevention available.
Pyrantel paralyzes and expels intestinal roundworms (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala) with each monthly dose. Large active dogs that spend time outdoors, interact with other dogs, or frequent dog parks face ongoing reinfection risk. Monthly Simparica Trio incorporates intestinal worm control into the same routine — no separate quarterly deworming tablet required.
Three proven active ingredients work through distinct mechanisms, covering every major parasite threat:
Yes. Smartway Pet Supplies ships from Australia, where Simparica Trio can be sold without a veterinary prescription. You can order the Green pack online and have it delivered directly to your US or Canadian address. Customers are responsible for compliance with their local import regulations.
Smartway supplies only 100% authentic Zoetis Simparica Trio sourced from licensed Australian veterinary wholesalers. Every order ships in original, manufacturer-sealed packaging with batch numbers, expiry dates, and the complete Zoetis label — identical to clinic supply.
Yes. Simparica Trio has been evaluated for safety and is approved for dogs 8 weeks and older. The Green pack is precisely dosed for the 44.3–88 lb range. As with all isoxazoline-class medications (sarolaner), use with caution in dogs with a history of seizures or neurological disorders.
Yes — and most owners find switching a significant simplification. Simparica Trio provides the heartworm protection of Heartgard Plus and the flea/tick coverage of NexGard, while also adding roundworm/hookworm treatment and extending tick coverage to six species. Switch at the start of the next monthly dose cycle.
Yes. Studies show over 98.9% efficacy against existing tick infestations within 48 hours of the first dose for most species. It begins killing deer ticks within 8 hours. For dogs entering heavy tick habitat, there is no meaningful delay in protection after the first dose.
A 6-month supply of Simparica Trio for large dogs at a US vet clinic typically runs $200–$260 USD, and Chewy requires an annual prescription. Smartway's pricing is substantially lower — and there's no prescription needed. Same product, significantly less cost.
Give a dose as soon as you remember, then resume monthly dosing from that date. If more than a few weeks have passed and your dog could have been exposed to heartworm, a vet test at your next opportunity is advisable before continuing.
this seems to be helping with the fleas so far and I was also worried about worms and that seems to be taken care of as well. Thank you so much for making. This is very smooth quick and easy process. received my order very quickly, much sooner than I expected.
Great on shipping. Very good price.
Excellent product
Even though I have to pay duties for this product to come to Canada 🇨🇦 it's still cheaper than getting it from the vet.
Plus having auto reorder is great except when you forget that it's set up and order the item again. 😀
Fast shipping, frequent communication from the seller! Very easy to do business with!
This is a great company to buy prescription meds for your pets without the need for a vet bill. I ordered from another company and never received my order. When I ordered from Smartway they let me know what was going on every step of the way. Also order arrived before it was supposed to.
Great product! The best flea pill on the market IMO!
everything is good
