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Simparica Trio
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If you're currently giving your small dog a separate heartworm tablet, flea treatment, and tick prevention, you already know how easy it is to miss a dose or lose track. Simparica Trio replaces all of that with one liver-flavored monthly chew. Specifically sized for dogs weighing 5.6–11 lbs (2.6–5 kg), the Purple pack delivers complete protection against heartworm disease, fleas, six tick species, roundworms, and hookworms — every month, in one step. No prescription required at Smartway Pet Supplies.
Heartworm is transmitted through mosquito bites and is present in all 50 US states. It's expensive to treat and can be fatal — but it's completely preventable with consistent monthly dosing. In studies supporting FDA approval, a single monthly dose of Simparica Trio provided 100% protection against heartworm disease. Moxidectin prevents Dirofilaria immitis larvae from developing before they can cause harm.
Fleas don't just cause itching. They spread disease, trigger flea allergy dermatitis (one of the most common reasons dogs visit the vet), and reproduce fast — one flea can lay up to 50 eggs a day. Simparica Trio starts killing adult fleas within 4 hours of dosing, with 100% flea elimination by 8 hours. Fleas die before they can lay eggs, breaking the infestation cycle in your home. It also prevents flea tapeworm (Dipylidium caninum) infection by eliminating the flea vector.
Simparica Trio is proven to kill all six of the most common tick species in North America:
Ticks are responsible for transmitting at least 15 serious diseases to dogs, including Lyme disease, ehrlichiosis, anaplasmosis, and Rocky Mountain spotted fever. Monthly Simparica Trio kills ticks before disease transmission can occur.
Simparica Trio holds a specific FDA approval to prevent infections that may cause Lyme disease — achieved by killing black-legged deer ticks before Borrelia burgdorferi can be transmitted. No other combination monthly oral chewable carries this FDA indication. This matters especially for dogs in high-risk areas: the Northeast, Mid-Atlantic states, upper Midwest, and the Pacific Coast.
Pyrantel paralyzes and expels intestinal roundworms (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala). Monthly Simparica Trio treats existing infections and prevents re-establishment. Hookworms in particular can cause serious blood loss in small dogs — ongoing monthly treatment keeps them clear.
Simparica Trio was the first product approved to combine sarolaner, moxidectin, and pyrantel in a single monthly chewable for dogs:
Yes. Smartway Pet Supplies is an Australian-based retailer, and Australian regulations permit the sale of Simparica Trio without a prescription requirement. Customers are responsible for ensuring compliance with import regulations in their country.
100% yes. All Simparica Trio sold by Smartway is authentic Zoetis product sourced from licensed Australian veterinary wholesalers. It arrives in original manufacturer-sealed packaging — identical to what your vet or Chewy stocks. We never sell grey-market, repackaged, or counterfeit product.
Orders are typically dispatched within 1–2 business days from our Melbourne warehouse. Standard shipping to the USA takes 7–14 business days. Free standard shipping applies on orders over $125.
Yes, Simparica Trio can be given with or without food. If your dog has a sensitive stomach, offering it alongside a small meal can reduce any chance of digestive upset.
Most dogs accept Simparica Trio as a treat due to its liver flavor. If your dog is reluctant, try offering it by hand, hiding it in a small amount of food, or sandwiching it in a pill pocket. Ensure the full chew is consumed for the complete dose.
Simparica Trio prevents flea tapeworm (Dipylidium caninum) by killing the fleas that carry tapeworm larvae. It does not treat tapeworms caused by other sources (e.g. from eating infected prey). If your dog hunts or scavenges, a separate tapeworm treatment may be needed.
Yes. You can transition from any other flea, tick, or heartworm preventive to Simparica Trio. Ideally, start Simparica Trio when the previous product's coverage period ends to avoid any overlap. If switching from a long-acting product like Bravecto, time the first Simparica Trio dose accordingly.
Yes. Simparica Trio is specifically weight-dosed — the Purple 5.6–11 lb size is formulated for the correct dose range for small breeds. Safe use in breeding, pregnant, or lactating dogs has not been fully evaluated; consult your vet if this applies to your dog.
I’m so happy I found this site. Everything was super easy and quick shipping. My cats are finally feeling relief.
Working great so far. Used it on 9 cats with no negative reactions.
Merci 👍🐕
They arrived great, worked great for the ear mites. Didn't take as long as we expected. Will definitely order from you again. Thanks.
this seems to be helping with the fleas so far and I was also worried about worms and that seems to be taken care of as well. Thank you so much for making. This is very smooth quick and easy process. received my order very quickly, much sooner than I expected.
The flea medication seems to be working keeping the fleas away. My cat isn’t itchy now!
Great on shipping. Very good price.
