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Simparica Trio
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Small dog owners know the challenge: a heartworm tablet, a flea treatment, tick prevention — keeping track of what's due and when. Simparica Trio eliminates that complexity entirely. One liver-flavored chew, given monthly, covers everything: heartworm disease, fleas, six species of ticks, Lyme disease prevention, roundworms, and hookworms. The Orange pack is sized for dogs 11.1–22 lbs (5.1–10 kg) — ideal for breeds like Beagles, Pugs, Cavaliers, Miniature Schnauzers, and Shih Tzus. Buy genuine Simparica Trio online from Smartway Pet Supplies — no vet prescription required, ships to the USA and Canada.
Heartworm disease is diagnosed in every state across the US and is potentially fatal. The treatment for established heartworm infection is lengthy, expensive, and hard on the dog. Prevention is simple: one monthly Simparica Trio chew. Moxidectin prevents Dirofilaria immitis larvae from developing into adult worms. FDA-approval studies confirmed 100% heartworm protection with consistent monthly dosing.
Sarolaner starts killing adult fleas within 4 hours of dosing and achieves 100% flea kill by 8 hours. Critically, fleas die before they can lay eggs — preventing the life cycle from completing and stopping re-infestation in your home environment. For dogs with flea allergy dermatitis (FAD), a condition caused by sensitivity to flea saliva, consistent monthly flea prevention is the most effective management strategy available. Simparica Trio also prevents flea tapeworm infection by eliminating the flea vectors that carry Dipylidium caninum larvae.
No other monthly oral combination preventive kills as many tick species as Simparica Trio. It provides proven, 30-day protection against:
Ticks transmit serious diseases including Lyme disease, ehrlichiosis, anaplasmosis, and Rocky Mountain spotted fever. Monthly Simparica Trio eliminates ticks rapidly — at 48 hours post-dose, efficacy against existing infestations exceeds 98.9% for most species.
Simparica Trio is the only combination monthly chewable that is FDA-approved to prevent infections that may cause Lyme disease, achieved by killing black-legged deer ticks before Borrelia burgdorferi bacteria can be transmitted. For dogs spending time in wooded or grassy areas in high-risk Lyme regions — particularly the Northeast, Great Lakes region, and Pacific Northwest — this is meaningful, specific protection.
Pyrantel treats and controls roundworm infections (Toxocara canis, Toxascaris leonina) and hookworm infections (Ancylostoma caninum, Uncinaria stenocephala). Hookworms are blood-feeders that can cause anaemia and weight loss in dogs. Roundworms are zoonotic and can be transmitted to humans. Monthly Simparica Trio treats existing infections and prevents re-infestation with each dose.
Simparica Trio was the first FDA-approved monthly chewable combining three proven parasiticide classes:
Yes. Smartway Pet Supplies operates from Australia, where Simparica Trio can be sold without a prescription requirement. You can order online and have it shipped directly to your US or Canadian address without needing a vet's prescription.
Yes — it is identical. Smartway sells only genuine, brand-name Zoetis Simparica Trio sourced from licensed Australian veterinary wholesalers. The product arrives in original, manufacturer-sealed packaging with the same formulation and efficacy as clinic or retail supply.
Significantly. A 6-month supply of Simparica Trio at a US vet or through Chewy (with prescription) typically costs $180–$230 USD depending on size. Smartway's pricing is substantially lower — plus you avoid the cost and inconvenience of getting a prescription renewed.
Standard shipping to the USA takes 7–14 business days from our Melbourne warehouse. Orders over $125 qualify for free standard shipping. Express delivery options are available at checkout.
Both. Simparica Trio kills existing adult fleas on your dog within 8 hours of the first dose, and prevents re-infestation by killing new fleas before they can lay eggs. For a heavy home infestation, an environmental flea spray may also help clear pupae from carpets and bedding faster.
Yes. If your dog is currently on a heartworm-only product like Heartgard, you can switch to Simparica Trio at the start of the next monthly dose cycle. Simparica Trio provides the same heartworm prevention plus flea, tick, and intestinal worm coverage in the same single monthly chew.
If your dog has been without heartworm prevention for more than a month or has never been tested, a heartworm test before starting is sensible. If your dog has a history of seizures, discuss with your vet first as sarolaner is an isoxazoline class drug.
this seems to be helping with the fleas so far and I was also worried about worms and that seems to be taken care of as well. Thank you so much for making. This is very smooth quick and easy process. received my order very quickly, much sooner than I expected.
The flea medication seems to be working keeping the fleas away. My cat isn’t itchy now!
Great on shipping. Very good price.
Medication works wonderfully.
I truly appreciate your service.
We should be able to buy this at any feed store here in USA without going through the veterinary system which is highly overpriced.
Good price and fast delivery.
The price was very reasonable and it arrived in a timely fashion
Same brand i use for my dogs at 1/2 the price of the vet.
