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Simparica Trio
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Simparica Trio is the most prescribed combination parasite preventive in the US — trusted by veterinarians for its breadth of coverage and reliability. The Blue pack covers medium dogs weighing 22.1–44 lbs (10.1–20 kg), making it the right choice for Cocker Spaniels, Bulldogs, Border Collies, Basset Hounds, Whippets, and similar breeds. One monthly chew delivers complete protection against heartworm disease, fleas, six species of ticks, Lyme disease, roundworms, and hookworms. Order genuine Simparica Trio from Smartway Pet Supplies — no vet prescription needed, ships direct to the USA and Canada.
Heartworm disease is present year-round across the entire continental US. Transmitted through a single mosquito bite, it causes progressive damage to the heart, lungs, and blood vessels — and treatment is costly, lengthy, and risky. Prevention is straightforward: one monthly Simparica Trio chew. In clinical studies supporting FDA approval, one dose provided 100% protection against heartworm disease. Moxidectin prevents Dirofilaria immitis larvae from reaching the adult stage that causes disease. Year-round continuous dosing is strongly recommended regardless of season or climate.
Fleas reproduce at extraordinary speed — a single female can lay 50 eggs per day. Within weeks, one flea on your dog can become a full home infestation living in carpets, furniture, and bedding. Simparica Trio interrupts this cycle at the source: it begins killing adult fleas in just 4 hours and achieves 100% flea kill within 8 hours. Fleas are eliminated before egg-laying, preventing re-infestation rather than just treating the visible symptom. Simparica Trio is also indicated for the treatment and prevention of flea allergy dermatitis and prevents flea tapeworm (Dipylidium caninum) by eliminating carrier fleas.
Simparica Trio was the first combination preventive proven to kill six tick species — a distinction no other monthly oral chewable currently matches:
Studies show Simparica Trio achieves over 98.9% efficacy against existing infestations of most species within 48 hours, and maintains 90%+ efficacy against re-infestation for at least 28 days.
Simparica Trio is FDA-approved to prevent infections that may cause Lyme disease by killing black-legged deer ticks — the tick species responsible for transmitting Borrelia burgdorferi. This is not just a general "tick coverage" claim: it is a specific, clinical FDA indication. For medium-sized active dogs that spend time outdoors — hiking, parks, trails, backyards in tick-heavy regions — this protection matters profoundly. Lyme disease can cause joint pain, fever, lethargy, and in severe cases, kidney disease in dogs.
Pyrantel provides monthly treatment and control of intestinal roundworm (Toxocara canis, Toxascaris leonina) and hookworm (Ancylostoma caninum, Uncinaria stenocephala) infections. Rather than requiring a separate quarterly or biannual worming treatment, Simparica Trio handles intestinal worm control as part of the same monthly dose.
Three distinct active ingredients, each targeting a different parasite class through different mechanisms:
Together, they do the work of up to three separate monthly treatments in a single palatable chew most dogs eat voluntarily as a treat.
Yes. Smartway Pet Supplies is an Australian-based retailer. Under Australian veterinary regulations, Simparica Trio can be sold without a prescription. You can order online and have it shipped directly to your US or Canadian door without needing a current vet prescription.
Yes — 100%. Smartway sells only authentic, brand-name Simparica Trio manufactured by Zoetis. We source exclusively from licensed Australian veterinary wholesalers and ship in original, manufacturer-sealed packaging. The product is identical in formulation and efficacy to what US vets and pet retailers carry.
Veterinary clinic markups on medications are significant — often 100–200% above wholesale cost — and prescription fees add further to the total. As an Australian retailer with no prescription requirement, Smartway passes these savings directly to you. You're buying the same genuine product at a fraction of the price.
Standard shipping to the US takes 7–14 business days; Canada is typically 10–18 business days. Orders over $125 ship free. Express options are available at checkout for faster delivery.
Yes. Heartworm is transmitted by mosquitoes, which remain active year-round in many US climates. Fleas can survive indoors through winter. Interrupting monthly dosing creates gaps in protection that can allow heartworm larvae to develop. Year-round continuous dosing is the standard recommendation.
Simparica Trio has no known contraindications and can generally be given alongside most common medications. If your dog is on epilepsy medication or has a known neurological condition, consult your vet before starting as sarolaner is an isoxazoline class compound.
The Blue pack (22.1–44 lbs) covers dogs up to 44 lbs. If your dog is at the top of that range or fluctuates, the Green pack (44.3–88 lbs) provides a safe margin. Overdosing by moving up one weight bracket is preferable to underdosing.
They provide broadly similar coverage but use different active ingredients. Simparica Trio uses sarolaner, moxidectin, and pyrantel. NexGard Spectra uses afoxolaner and milbemycin oxime. Simparica Trio is the only combination chewable FDA-approved to prevent Lyme disease and covers six tick species. Both are effective; individual dogs may respond differently or have preferences.
this seems to be helping with the fleas so far and I was also worried about worms and that seems to be taken care of as well. Thank you so much for making. This is very smooth quick and easy process. received my order very quickly, much sooner than I expected.
The flea medication seems to be working keeping the fleas away. My cat isn’t itchy now!
Great on shipping. Very good price.
Medication works wonderfully.
I truly appreciate your service.
We should be able to buy this at any feed store here in USA without going through the veterinary system which is highly overpriced.
Good price and fast delivery.
The price was very reasonable and it arrived in a timely fashion
Same brand i use for my dogs at 1/2 the price of the vet.
