• Simparica Trio Chewables For Medium Dogs 22.1-44lbs 10.1-20Kg Blue 3 Chews – front of pack
  • Simparica Trio Chewables For Medium Dogs 22.1-44lbs 10.1-20Kg Blue – back of pack
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Simparica Trio Chewables For Medium Dogs 22.1–44lbs (10.1-20Kg) Blue
$83.00 USD
$83.00 USD $83.00 USD
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  • ✔ Genuine branded product (sealed & in-date)
  • ✔ Ships from Australia with tracked delivery
  • ✔ No prescription required
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Description

The #1 Vet-Prescribed Dog Parasite Preventive — Now Available Online Without a Prescription

Simparica Trio is the most prescribed combination parasite preventive in the US — trusted by veterinarians for its breadth of coverage and reliability. The Blue pack covers medium dogs weighing 22.1–44 lbs (10.1–20 kg), making it the right choice for Cocker Spaniels, Bulldogs, Border Collies, Basset Hounds, Whippets, and similar breeds. One monthly chew delivers complete protection against heartworm disease, fleas, six species of ticks, Lyme disease, roundworms, and hookworms. Order genuine Simparica Trio from Smartway Pet Supplies — no vet prescription needed, ships direct to the USA and Canada.

What One Monthly Chew Covers

Heartworm Disease — 100% Protection Confirmed in Studies

Heartworm disease is present year-round across the entire continental US. Transmitted through a single mosquito bite, it causes progressive damage to the heart, lungs, and blood vessels — and treatment is costly, lengthy, and risky. Prevention is straightforward: one monthly Simparica Trio chew. In veterinary clinical studies, one dose provided 100% protection against heartworm disease. Moxidectin prevents Dirofilaria immitis larvae from reaching the adult stage that causes disease. Year-round continuous dosing is strongly recommended regardless of season or climate.

Fleas — Kills Before They Can Reproduce

Fleas reproduce at extraordinary speed — a single female can lay 50 eggs per day. Within weeks, one flea on your dog can become a full home infestation living in carpets, furniture, and bedding. Simparica Trio interrupts this cycle at the source: it begins killing adult fleas in just 4 hours and achieves 100% flea kill within 8 hours. Fleas are eliminated before egg-laying, preventing re-infestation rather than just treating the visible symptom. Simparica Trio is also indicated for the treatment and prevention of flea allergy dermatitis and prevents flea tapeworm (Dipylidium caninum) by eliminating carrier fleas.

6 Types of Ticks — More Species Than Any Other Monthly Oral Chew

Simparica Trio was the first combination preventive proven to kill six tick species — a distinction no other monthly oral chewable currently matches:

  • Lone Star tick (Amblyomma americanum)
  • Gulf Coast tick (Amblyomma maculatum)
  • American dog tick (Dermacentor variabilis)
  • Black-legged (deer) tick (Ixodes scapularis)
  • Brown dog tick (Rhipicephalus sanguineus)
  • Asian longhorned tick (Haemaphysalis longicornis)

Studies show Simparica Trio achieves over 98.9% efficacy against existing infestations of most species within 48 hours, and maintains 90%+ efficacy against re-infestation for at least 28 days.

Lyme Disease Prevention — The Only Combination Chew with This Benefit

Simparica Trio is clinically proven to help prevent infections that may cause Lyme disease by killing black-legged deer ticks — the tick species responsible for transmitting Borrelia burgdorferi. This is not just a general "tick coverage" claim: it is a specific, clinically proven benefit. For medium-sized active dogs that spend time outdoors — hiking, parks, trails, backyards in tick-heavy regions — this protection matters profoundly. Lyme disease can cause joint pain, fever, lethargy, and in severe cases, kidney disease in dogs.

Roundworms & Hookworms — Monthly Control Built In

Pyrantel provides monthly treatment and control of intestinal roundworm (Toxocara canis, Toxascaris leonina) and hookworm (Ancylostoma caninum, Uncinaria stenocephala) infections. Rather than requiring a separate quarterly or biannual worming treatment, Simparica Trio handles intestinal worm control as part of the same monthly dose.

How Simparica Trio Works

Three distinct active ingredients, each targeting a different parasite class through different mechanisms:

  • Sarolaner — an isoxazoline that selectively disrupts the GABA-gated chloride channel in arthropods. Fleas and ticks die rapidly when they bite your dog because sarolaner is present in the bloodstream throughout the month.
  • Moxidectin — a macrocyclic lactone that is absorbed systemically. It interferes with chloride channel neurotransmission in heartworm larvae, preventing them from developing into the adult stage.
  • Pyrantel pamoate — a tetrahydropyrimidine that acts as a depolarizing neuromuscular blocking agent in intestinal nematodes. Roundworms and hookworms are paralyzed and expelled safely.

Together, they do the work of up to three separate monthly treatments in a single palatable chew most dogs eat voluntarily as a treat.

Dosing Information

  • One chew monthly for dogs weighing 22.1–44 lbs (10.1–20 kg)
  • Administer with or without food
  • Safe from 8 weeks of age and 2.8 lbs minimum weight
  • Give monthly throughout the year for continuous protection
  • Ensure the full chew is consumed for a complete dose

Helpful Guides

Shop All Simparica Trio Sizes

Frequently asked questions

Can I buy Simparica Trio without a vet prescription at Smartway?

Yes. Smartway Pet Supplies is an Australian-based retailer. Under Australian veterinary regulations, Simparica Trio can be sold without a prescription. You can order online and have it shipped directly to your US or Canadian door without needing a current vet prescription.

Is the Simparica Trio sold by Smartway genuine Zoetis product?

Yes — 100%. Smartway sells only authentic, brand-name Simparica Trio manufactured by Zoetis. We source exclusively from licensed Australian veterinary wholesalers and ship in original, manufacturer-sealed packaging. The product is identical in formulation and efficacy to what US vets and pet retailers carry.

Why is Simparica Trio cheaper at Smartway than at my vet?

Veterinary clinic markups on medications are significant — often 100–200% above wholesale cost — and prescription fees add further to the total. As an Australian retailer with no prescription requirement, Smartway passes these savings directly to you. You're buying the same genuine product at a fraction of the price.

How long does shipping take to the USA and Canada?

Standard shipping to the US takes 7–14 business days; Canada is typically 10–18 business days. Orders over $125 ship free. Express options are available at checkout for faster delivery.

Does Simparica Trio need to be given monthly even in winter?

Yes. Heartworm is transmitted by mosquitoes, which remain active year-round in many US climates. Fleas can survive indoors through winter. Interrupting monthly dosing creates gaps in protection that can allow heartworm larvae to develop. Year-round continuous dosing is the standard recommendation.

Can Simparica Trio be given alongside other medications?

Simparica Trio has no known contraindications and can generally be given alongside most common medications. If your dog is on epilepsy medication or has a known neurological condition, consult your vet before starting as sarolaner is an isoxazoline class compound.

What size should I choose if my dog weighs exactly 44 lbs?

The Blue pack (22.1–44 lbs) covers dogs up to 44 lbs. If your dog is at the top of that range or fluctuates, the Green pack (44.3–88 lbs) provides a safe margin. Overdosing by moving up one weight bracket is preferable to underdosing.

Is Simparica Trio the same as NexGard Spectra?

They provide broadly similar coverage but use different active ingredients. Simparica Trio uses sarolaner, moxidectin, and pyrantel. NexGard Spectra uses afoxolaner and milbemycin oxime. Simparica Trio is the only combination chewable clinically proven to help prevent Lyme disease, and it covers six tick species. Both are effective; individual dogs may respond differently or have preferences.