Stop Juggling Separate Treatments — Simparica Trio Does It All in One Monthly Chew

If you're currently giving your small dog a separate heartworm tablet, flea treatment, and tick prevention, you already know how easy it is to miss a dose or lose track. Simparica Trio replaces all of that with one liver-flavored monthly chew. Specifically sized for dogs weighing 5.6–11 lbs (2.6–5 kg), the Purple pack delivers complete protection against heartworm disease, fleas, six tick species, roundworms, and hookworms — every month, in one step. No prescription required at Smartway Pet Supplies.

Complete Monthly Parasite Coverage

Heartworm Disease — 100% Protection Per Dose

Heartworm is transmitted through mosquito bites and is present in all 50 US states. It's expensive to treat and can be fatal — but it's completely preventable with consistent monthly dosing. In veterinary clinical studies, a single monthly dose of Simparica Trio provided 100% protection against heartworm disease. Moxidectin prevents Dirofilaria immitis larvae from developing before they can cause harm.

Fleas — Kills in 4 Hours, 100% by 8 Hours

Fleas don't just cause itching. They spread disease, trigger flea allergy dermatitis (one of the most common reasons dogs visit the vet), and reproduce fast — one flea can lay up to 50 eggs a day. Simparica Trio starts killing adult fleas within 4 hours of dosing, with 100% flea elimination by 8 hours. Fleas die before they can lay eggs, breaking the infestation cycle in your home. It also prevents flea tapeworm (Dipylidium caninum) infection by eliminating the flea vector.

Six Tick Species — More Than Any Other Monthly Oral Chew

Simparica Trio is proven to kill all six of the most common tick species in North America:

• Lone Star tick (Amblyomma americanum)
• Gulf Coast tick (Amblyomma maculatum)
• American dog tick (Dermacentor variabilis)
• Black-legged (deer) tick (Ixodes scapularis)
• Brown dog tick (Rhipicephalus sanguineus)
• Asian longhorned tick (Haemaphysalis longicornis)

Ticks are responsible for transmitting at least 15 serious diseases to dogs, including Lyme disease, ehrlichiosis, anaplasmosis, and Rocky Mountain spotted fever. Monthly Simparica Trio kills ticks before disease transmission can occur.

Lyme Disease Prevention

Simparica Trio is clinically proven to help prevent infections that may cause Lyme disease — achieved by killing black-legged deer ticks before Borrelia burgdorferi can be transmitted. No other combination monthly oral chewable carries this specific benefit. This matters especially for dogs in high-risk areas: the Northeast, Mid-Atlantic states, upper Midwest, and the Pacific Coast.

Roundworms & Hookworms — Treated and Controlled

Pyrantel paralyzes and expels intestinal roundworms (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala). Monthly Simparica Trio treats existing infections and prevents re-establishment. Hookworms in particular can cause serious blood loss in small dogs — ongoing monthly treatment keeps them clear.

Three Active Ingredients, One Chew

Simparica Trio was the first product to combine sarolaner, moxidectin, and pyrantel in a single monthly chewable for dogs:

• Sarolaner — rapidly kills fleas and ticks by disrupting their nervous system. Acts within hours of first contact through your dog's bloodstream.
• Moxidectin — absorbed systemically, prevents heartworm larvae from maturing into the adult worms that cause disease.
• Pyrantel pamoate — paralyzes intestinal nematodes (roundworms and hookworms) so they can be safely expelled.

Dosing Information

• One chew monthly for dogs weighing 5.6–11 lbs (2.6–5 kg)
• Administer with or without food
• Safe for dogs and puppies 8 weeks of age and older
• Ensure the dog consumes the full chew
• For continuous protection, give monthly without gaps year-round

Frequently Asked Questions

Can I buy Simparica Trio without a vet prescription?

Yes. Smartway Pet Supplies is an Australian-based retailer, and Australian regulations permit the sale of Simparica Trio without a prescription requirement. Customers are responsible for ensuring compliance with import regulations in their country.

Is Smartway's Simparica Trio genuine product?

100% yes. All Simparica Trio sold by Smartway is authentic Zoetis product sourced from licensed Australian veterinary wholesalers. It arrives in original manufacturer-sealed packaging — identical to what your vet or Chewy stocks. We never sell grey-market, repackaged, or counterfeit product.

How soon after my order will it ship?

Orders are typically dispatched within 1–2 business days from our Melbourne warehouse. Standard shipping to the USA takes 7–14 business days. Free standard shipping applies on orders over $125.

Can I give Simparica Trio with food?

Yes, Simparica Trio can be given with or without food. If your dog has a sensitive stomach, offering it alongside a small meal can reduce any chance of digestive upset.

What if my dog doesn't eat the chew voluntarily?

Most dogs accept Simparica Trio as a treat due to its liver flavor. If your dog is reluctant, try offering it by hand, hiding it in a small amount of food, or sandwiching it in a pill pocket. Ensure the full chew is consumed for the complete dose.

Does Simparica Trio cover tapeworms?

Simparica Trio prevents flea tapeworm (Dipylidium caninum) by killing the fleas that carry tapeworm larvae. It does not treat tapeworms caused by other sources (e.g. from eating infected prey). If your dog hunts or scavenges, a separate tapeworm treatment may be needed.

Can I switch from another monthly preventive to Simparica Trio?

Yes. You can transition from any other flea, tick, or heartworm preventive to Simparica Trio. Ideally, start Simparica Trio when the previous product's coverage period ends to avoid any overlap. If switching from a long-acting product like Bravecto, time the first Simparica Trio dose accordingly.

Is Simparica Trio safe for small dog breeds?

Yes. Simparica Trio is specifically weight-dosed — the Purple 5.6–11 lb size is formulated for the correct dose range for small breeds. Safe use in breeding, pregnant, or lactating dogs has not been fully evaluated; consult your vet if this applies to your dog.

Helpful Guides

• How Long Does Simparica Trio Take to Work?
• NexGard Spectra vs Simparica Trio: The Full Comparison
• Bravecto vs Simparica Trio: Which Is Better?
• Can You Buy Simparica Trio Without a Vet Prescription?

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• View all Simparica Trio weight sizes