Simparica Trio for Giant Breeds — Complete Monthly Protection Sized for the Biggest Dogs

Giant breeds like Great Danes, Mastiffs, Saint Bernards, Rottweilers, and large Malinois deserve protection that fully matches their size. The Simparica Trio Red pack is precisely dosed for dogs weighing 88.1–132 lbs (40.1–60 kg) — delivering the same comprehensive monthly parasite coverage trusted by veterinarians and over 15 million dogs in the US. One liver-flavored chew every month prevents heartworm disease, kills fleas and six species of ticks, prevents Lyme disease, and treats roundworms and hookworms. Buy genuine Simparica Trio online without a prescription from Smartway Pet Supplies — ships to the USA and Canada.

Complete Protection: What Every Dose Covers

Heartworm Disease — The Most Serious Preventable Threat

Heartworm disease affects dogs in every US state and is transmitted through a single mosquito bite. Adult heartworms live in the heart and pulmonary arteries, causing severe respiratory and cardiovascular damage over time. Treatment is long, expensive, and carries real risk — but prevention is as simple as one monthly chew. Moxidectin in Simparica Trio prevents Dirofilaria immitis larvae from developing into adult worms. FDA-approval studies confirmed 100% heartworm protection with a single monthly dose. There is no effective alternative to consistent monthly prevention.

Fleas — Eliminated Before They Can Establish

Giant breed dogs spend more time outdoors and often interact with other dogs, increasing flea exposure. A single flea that goes untreated can rapidly produce thousands of offspring in your home environment — eggs and larvae living in carpet and furniture for months. Simparica Trio ends this cycle fast: it starts killing adult fleas within 4 hours and achieves 100% flea kill within 8 hours of dosing. Fleas die before laying eggs, preventing home infestation at the source. Monthly dosing also prevents flea allergy dermatitis (FAD) and eliminates fleas that carry Dipylidium caninum flea tapeworm larvae.

Six Tick Species — The Most Comprehensive Tick Coverage in a Monthly Chew

No other monthly combination oral chewable for dogs is proven to kill as many tick species as Simparica Trio. Every dose provides 30 days of protection against all six major North American tick species:

• Lone Star tick (Amblyomma americanum)
• Gulf Coast tick (Amblyomma maculatum)
• American dog tick (Dermacentor variabilis)
• Black-legged (deer) tick (Ixodes scapularis)
• Brown dog tick (Rhipicephalus sanguineus)
• Asian longhorned tick (Haemaphysalis longicornis)

Clinical studies confirm Simparica Trio achieves over 98.9% efficacy against existing tick infestations of most species within 48 hours of the first dose, with sustained 90%+ efficacy against re-infestation for at least 28 days.

Lyme Disease Prevention — FDA-Approved, Clinically Proven

Simparica Trio is the only combination monthly chewable that is FDA-approved to prevent infections that may cause Lyme disease, achieved by killing black-legged deer ticks before Borrelia burgdorferi can be transmitted. Large working dogs, hunting dogs, and giant breeds that cover significant terrain face real ongoing Lyme exposure. This specific FDA approval — not just general "tick coverage" — distinguishes Simparica Trio from competing products.

Roundworms & Hookworms — Ongoing Intestinal Worm Control

Large active dogs face persistent reinfection risk from intestinal worms, particularly roundworms (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala) encountered in soil, grass, and from other infected animals. Pyrantel treats and controls these infections monthly — building intestinal worm control directly into your dog's standard parasite prevention routine rather than requiring separate quarterly treatments.

Three Active Ingredients Working Together

Simparica Trio was the first and remains the standard for triple-combination monthly parasite prevention:

• Sarolaner — an isoxazoline that selectively blocks GABA-gated and glutamate-gated chloride channels in insects and acarines, causing rapid uncontrolled nervous system activity, paralysis, and death. Fleas are killed within 4 hours; ticks within 8–48 hours depending on species.
• Moxidectin — a macrocyclic lactone absorbed systemically. It interferes with chloride channel-mediated neurotransmission in heartworm larvae (Dirofilaria immitis), preventing larval development through the L4 stage before adult worms can establish in the heart and pulmonary vasculature.
• Pyrantel pamoate — a depolarizing neuromuscular blocking agent that causes spastic paralysis in intestinal roundworms and hookworms, allowing safe elimination from the gastrointestinal tract.

Together, these three mechanisms replace up to three separate monthly treatments in a single palatable, liver-flavored chew that most large dogs accept without hesitation.

Dosing Information

• One chew monthly for dogs weighing 88.1–132 lbs (40.1–60 kg)
• Administer with or without food
• Safe for dogs from 8 weeks of age and weighing at least 2.8 lbs minimum
• For dogs over 132 lbs, use the appropriate combination of sizes to cover the full weight
• Ensure the full chew is consumed for a complete monthly dose
• Year-round continuous monthly dosing is strongly recommended

Frequently Asked Questions

Can I buy Simparica Trio for giant breeds without a prescription?

Yes. Smartway Pet Supplies is based in Australia, where Simparica Trio can be sold without a prescription requirement. You can order the Red pack online and have it shipped directly to your door in the USA or Canada — no vet prescription needed. Customers should ensure their order complies with applicable import regulations.

Is Smartway selling the genuine Zoetis Simparica Trio?

Yes — 100% authentic. Smartway sources only brand-name Simparica Trio from licensed Australian veterinary wholesalers. Every shipment arrives in original, manufacturer-sealed Zoetis packaging with full labelling, batch numbers, and expiry dates. You receive exactly the same product your vet stocks.

My dog is 120 lbs — is the Red pack the right choice?

Yes. The Red pack covers dogs from 88.1 up to 132 lbs — your 120 lb dog falls squarely within this range and will receive the correct dose. If your dog is close to or just over 132 lbs, contact us and we can advise on correct dosing.

How much can I save compared to a US vet prescription?

A 6-month supply of Simparica Trio for extra large dogs from a US vet or Chewy typically costs $210–$270 USD (plus any prescription or exam costs). Smartway's pricing is significantly lower — same genuine product, no prescription required, delivered to your door.

Is Simparica Trio safe for giant breed dogs with joint issues or other health conditions?

Simparica Trio has no known contraindications for dogs with orthopedic conditions, joint disease, or most chronic health conditions. The one exception to discuss with your vet is a history of seizures or neurological disorders, as sarolaner is an isoxazoline-class compound. For all other health situations, Simparica Trio is generally considered safe.

Does the large dog size provide the same efficacy as smaller doses?

Yes. Simparica Trio is weight-dosed: the Red pack delivers the correct mg/kg of each active ingredient for the 88.1–132 lb range. Efficacy is equivalent across all weight sizes — all have the same FDA-confirmed 100% heartworm protection and the same flea, tick, and intestinal worm coverage.

How long does shipping take to the USA?

Standard shipping to the US takes 7–14 business days from our Melbourne warehouse. Orders over $125 qualify for free standard shipping. Express shipping is available at checkout for faster delivery.

What if my giant breed dog is reluctant to take the chew?

Most dogs accept Simparica Trio as a treat due to its pork liver flavor. If your dog is reluctant, try offering it by hand, hiding it in a small amount of wet food, or using a pill pocket. The full chew must be consumed to deliver a complete dose — partial consumption should be followed by a second full chew.

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Shop All Simparica Trio Sizes

• View all Simparica Trio weight sizes