• HeartGard Plus Large Dogs 23-45kg Blue – front of pack
  • HeartGard Plus Chewables for Large Dogs 51-100 lbs 23-45 kg - Brown – back of pack
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HeartGard Plus Chewables for Large Dogs 51–100 lbs (23–45 kg) – Brown
$79.00 USD
$79.00 USD $79.00 USD
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  • ✔ Genuine branded product (sealed & in-date)
  • ✔ Ships from Australia with tracked delivery
  • ✔ No prescription required
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Size

Description

HeartGard Plus Chewables for Large Dogs 51–100 lbs (23–45 kg) – Heartworm & Worm Prevention (Brown)

HeartGard Plus Chewables for Large Dogs deliver monthly heartworm prevention plus treatment for common intestinal worms in a soft, real beef chew most dogs eat like a treat. Specifically dosed for large dogs weighing 51–100 lbs (23–45 kg), HeartGard Plus (Brown) protects against heartworm disease and treats roundworm and hookworm with one chew, once a month.

What HeartGard Plus Protects Against

  • Heartworm: Prevents heartworm disease, transmitted by infected mosquitoes.
  • Roundworm: Treats and controls Toxocara canis and Toxascaris leonina infections.
  • Hookworm: Treats and controls Ancylostoma caninum and Uncinaria stenocephala infections.

Not covered: Fleas, ticks, tapeworm, or whipworm. For flea and tick protection, pair HeartGard Plus with NexGard, Bravecto, or a similar product.

Why Large-Dog Owners Choose HeartGard Plus

  • #1 vet-recommended brand: The most-prescribed heartworm preventative in the US for decades.
  • Real beef chew: Made with real beef (not beef-flavored) — even fussy large dogs eat it eagerly.
  • Cost-effective for large breeds: One monthly chew at a reasonable price — large-dog parasite protection adds up, and HeartGard Plus is well-priced for the value.
  • Intestinal worm coverage: Treats common roundworm and hookworm infections without a separate wormer.
  • Right size: The Brown pack is dosed for dogs 51–100 lbs — covers most adult Labradors, Golden Retrievers, German Shepherds, and similar large breeds.

How HeartGard Plus Works

HeartGard Plus combines two active ingredients:

  • Ivermectin targets immature heartworm larvae (microfilariae) before they can mature into adult heartworms — stopping the disease before it establishes.
  • Pyrantel pamoate paralyzes and clears adult roundworm and hookworm infections in the intestinal tract.

Who It’s For

  • Large dogs weighing 51–100 lbs (23–45 kg)
  • Puppies and adult dogs 6 weeks of age and older
  • Healthy dogs — talk to your vet before use in herding breeds known to carry the MDR1 gene mutation

How to Give HeartGard Plus

  1. Give one chew per month, on the same date each month, year-round.
  2. Offer directly as a treat — most large dogs eagerly accept the real beef flavor.
  3. Make sure your dog chews and swallows the full chew.
  4. If your dog is starting heartworm prevention for the first time at 7 months or older, your vet may recommend a heartworm test first.

Safety & Side Effects

HeartGard Plus is well tolerated by most dogs. Mild, short-lived side effects can include vomiting, diarrhea, lethargy, or reduced appetite.

Important note for Collie / herding-breed owners: Some Collies, Australian Shepherds, Old English Sheepdogs, and related breeds carry the MDR1 gene mutation, which can make them sensitive to ivermectin at high doses. At the dose used in HeartGard Plus, the product is considered safe for these breeds — but if your dog has tested positive for MDR1, talk to your veterinarian before starting.

Product Details

  • Brand: HeartGard Plus (Boehringer Ingelheim)
  • For: Dogs
  • Weight range: 51–100 lbs (23–45 kg)
  • Pack color: Brown
  • Form: Real-beef soft chew (oral)
  • Active ingredients: Ivermectin + Pyrantel pamoate
  • Minimum age: 6 weeks
  • Pack size: 6 chews (6 months of protection)
  • Coverage: Heartworm prevention + roundworm and hookworm treatment

Helpful Links

Fast shipping across the US & Canada — no prescription required. Use only as directed on the packaging. Information provided for general reference; speak with your veterinarian for medical advice specific to your dog.

 

Frequently asked questions

Is Brown the right pack for my Labrador, Golden Retriever, or German Shepherd?

Most adult Labradors, Golden Retrievers, German Shepherds, Boxers, and similar large breeds fall within the Brown range (51–100 lbs). Weigh your dog to confirm — especially Labs and Goldens, which can exceed 100 lbs in some lines.

My dog is over 100 lbs — what do I use?

For dogs over 100 lbs (typically Great Danes, Mastiffs, large Bernese Mountain Dogs, etc.), your vet may recommend combining HeartGard Plus packs to reach the correct ivermectin dose for body weight. Don’t do this without veterinary guidance — the exact combination depends on your dog’s weight.

Is this the same HeartGard Plus my vet sells?

Yes — it’s the same HeartGard Plus product manufactured by Boehringer Ingelheim, with the same active ingredients (ivermectin + pyrantel pamoate) at the same dosages. The only difference is you’re buying it directly from us, over the counter, without a prescription fee.

What’s the difference between HeartGard Plus and NexGard?

HeartGard Plus prevents heartworm and treats intestinal worms. NexGard covers fleas and ticks. They’re complementary products that many dog owners use together for full parasite coverage. NexGard Spectra combines both into one chew if you prefer a single-product approach.

Do I need a prescription to buy HeartGard Plus?

No — SmartWay Pet Supplies ships HeartGard Plus over the counter to customers across the US and Canada. No prescription or vet authorization required at checkout.

Is HeartGard Plus safe for Collies and herding breeds?

At the dose used in HeartGard Plus, the product is generally considered safe for Collies, Australian Shepherds, Shetland Sheepdogs, and other herding breeds. If your dog has tested positive for the MDR1 gene mutation, talk to your veterinarian before starting.