• Simparica Trio Chewables For Puppies 2.8-5.5lbs 1.25-2.5Kg Yellow 3pk – front of pack
  • Simparica Trio Chewables For Puppies 2.8-5.5lbs 1.25-2.5Kg Yellow 3pk – back of pack
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Simparica Trio Chewables For Puppies 2.8-5.5lbs (1.25-2.5Kg) Yellow
$59.00 USD
$59.00 USD $59.00 USD
On Sale Sold out
  • ✔ Genuine branded product (sealed & in-date)
  • ✔ Ships from Australia with tracked delivery
  • ✔ No prescription required
Shipping calculated at checkout.

Description

Start Protection Early — Simparica Trio for Puppies From 8 Weeks Old

The first months of a puppy's life are when parasite protection matters most — and Simparica Trio gives you the most complete protection available in a single monthly chew. Designed for the smallest dogs and puppies weighing 2.8–5.5 lbs (1.25–2.5 kg), this liver-flavored chewable tablet covers heartworm disease, fleas, six species of ticks, roundworms, and hookworms from just 8 weeks of age. No prescription required when you order from Smartway Pet Supplies — genuine Zoetis product shipped direct to the USA and Canada.

What Simparica Trio Protects Against

Heartworm Disease — 100% Protection

Heartworm disease is transmitted by a single mosquito bite and can be fatal if left untreated. Starting your puppy on Simparica Trio early gives them continuous monthly protection against Dirofilaria immitis. In veterinary clinical studies, one monthly dose provided 100% protection against heartworm disease.

Fleas — Starts Killing in 4 Hours

Simparica Trio begins killing fleas within 4 hours of the first dose and achieves 100% flea kill within 8 hours. Crucially, it kills fleas before they can lay eggs — breaking the infestation cycle in your home rather than just treating the dog. Flea allergy dermatitis (FAD) is one of the most common skin conditions in dogs; consistent monthly protection prevents it before it starts. Simparica Trio also eliminates fleas that carry flea tapeworm larvae, preventing Dipylidium caninum infection.

Six Species of Ticks

Simparica Trio is the first combination preventive proven to kill six species of ticks — more than any competing oral monthly chewable:

  • Lone Star tick (Amblyomma americanum)
  • Gulf Coast tick (Amblyomma maculatum)
  • American dog tick (Dermacentor variabilis)
  • Black-legged (deer) tick (Ixodes scapularis)
  • Brown dog tick (Rhipicephalus sanguineus)
  • Asian longhorned tick (Haemaphysalis longicornis)

Lyme Disease Prevention

Simparica Trio is clinically proven to help prevent infections that may cause Lyme disease by killing black-legged deer ticks before they can transmit Borrelia burgdorferi. It is the only combination monthly chewable proven for this specific benefit — important for dogs in the Northeast, Mid-Atlantic, Midwest, and Pacific Northwest where Lyme disease risk is highest.

Roundworms & Hookworms

Pyrantel treats and controls intestinal roundworm (Toxocara canis, Toxascaris leonina) and hookworm (Ancylostoma caninum, Uncinaria stenocephala) infections. For puppies especially — who are at higher risk of roundworm infection from their mother — this is an important part of routine deworming.

How It Works: Three Active Ingredients in One Chew

Simparica Trio was the first product to combine all three of these proven active ingredients:

  • Sarolaner — an isoxazoline that attacks the GABA receptor system in fleas and ticks, causing rapid paralysis and death when they bite your dog.
  • Moxidectin — absorbed systemically after dosing, it prevents heartworm (Dirofilaria immitis) larvae from developing into adult worms.
  • Pyrantel pamoate — acts as a depolarizing neuromuscular blocker in intestinal roundworms and hookworms, causing paralysis and expulsion.

One chew effectively replaces the work of two or three separate monthly treatments.

Dosing Information

  • One chew monthly for puppies and dogs weighing 2.8–5.5 lbs (1.25–2.5 kg)
  • Administer with or without food
  • Safe for puppies from 8 weeks of age weighing at least 2.8 lbs
  • Give the full chew; ensure the dog has consumed it entirely
  • Year-round monthly use is recommended for continuous protection

Helpful Guides

Shop All Simparica Trio Sizes

Frequently asked questions

Can I buy Simparica Trio without a vet prescription?

Yes. At Smartway Pet Supplies, you can purchase Simparica Trio without a prescription. We are an Australian-based retailer, and Australian regulations allow the sale of this product without a prescription requirement. Customers are responsible for ensuring their order complies with import regulations in their destination country.

Is the Simparica Trio from Smartway genuine Zoetis product?

Absolutely. We sell only 100% authentic, brand-name Simparica Trio manufactured by Zoetis. All products are sourced from licensed Australian veterinary wholesalers and arrive in original, manufacturer-sealed packaging. You will never receive grey-market, repackaged, or counterfeit product from Smartway.

How long does shipping take to the USA?

Standard shipping to the USA typically takes 7–14 business days. Orders over $125 qualify for FREE standard shipping. Express options are available at checkout.

Can Simparica Trio be given to a puppy with no prior parasite treatment?

Yes. Simparica Trio can be started at any time of year. For the best protection, begin monthly doses before ticks or mosquitoes become active in your region and continue year-round without interruption.

Should I do a heartworm test before starting Simparica Trio?

If your dog has never been on heartworm prevention or has had a lapse in coverage, a heartworm test is recommended before starting. This is because giving a preventive to a dog that already has adult heartworms can cause a reaction. Consult your vet if you're unsure.

What if my puppy spits out or vomits the chew?

If vomiting occurs within an hour of dosing, re-administer a full replacement dose. Giving the chew with a small amount of food can reduce the chance of an upset stomach.

What's the difference between Simparica and Simparica Trio?

Simparica contains only sarolaner and covers fleas and ticks. Simparica Trio adds moxidectin and pyrantel, extending coverage to heartworm disease, roundworms, and hookworms. For most dog owners, Simparica Trio is the better choice because it replaces multiple products in one monthly chew.

Is Simparica Trio safe for dogs with a history of seizures?

Use with caution. Sarolaner is a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in some dogs. If your dog has a history of seizures or neurological disorders, discuss with your vet before starting.